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A ‘Game Changer’ For Organ Transplants: Blood Type of Donor Kidneys Altered in Breakthrough Research_我的网站

冰与火之歌第一季

A |

放在五年前，你要是去看一场国内顶级马拉松的领奖台，放眼望去，选手脚上基本都是几个熟悉的国际大牌logo。 Breakthrough new research could significantly increase supply of organs for people with rarer blood types waiting for a transplant, reported The Guardian.,A team of scientists from the University of Cambridge have successfully altered the blood type of three donor kidneys. By flushing blood infused with a special enzyme through a human kidney the scientists removed the blood type markers lining the blood vessels of the organ.,The procedure required using a device that is connected with a donor’s kidney to pass oxygenated blood through it - a normothermic perfusion machine. As a result, the organ was converted to type O, considered the universal donor.,Blood Group Compatible,As the blood type of a donor must be compatible with the recipient’s, the new development could increase the supply of kidneys available for transplant.,A kidney from someone with blood type A cannot be transplanted to someone with blood type B, or visa versa. In such a case, the receiving body’s immune system would reject the new organ, interpreting the different blood type as foreign.,So changing the blood type to the universal O would mean the donor organ could be used for people with any blood type.,“Our confidence was really boosted after we applied the enzyme to a piece of human kidney tissue and saw very quickly that the antigens were removed. After this, we knew that the process is feasible, and we just had to scale up the project to apply the enzyme to full-size human kidneys,” Serena MacMillan, a PhD student at the University of Cambridge, said.,Scientists involved in the research, funded by charity Kidney Research UK and due to be published in the British Journal of Surgery, clarified that the outcome might have particular implications for minority ethnic groups.,Science & TechGood News for ABs: Scientists Can Now Change People's Blood Type21 February, 16:34 GMT,Some blood groups such as O Rh positive and B Rh positive are more prevalent among black, Asian and minority ethnic communities. To complicate matters further, some rare blood types are only found within the black, Asian and minority ethnic communities,This typically places them at a disadvantage, as they struggle to find a match. With low donation rates from these populations, stressed the researchers, sometimes such patients wait for as long as over a year for a compatible donor. They cited figures from 2020-21 showing that just over 9% of total organ donations in the UK came from black and minority ethnic donors. On the other hand, black and minority ethnic patients make up 33% of the kidney transplant waiting list.,“It’s very exciting to think about how this could potentially impact so many lives,” added Serena MacMillan.,The “potentially gamechanging” research was applauded by Dr Aisling McMahon, the executive director of research at Kidney Research UK.,The scientists will now test the reintroduction of other blood types and observe how the novel approach in clinical settings.。高端竞速跑鞋市场被外资垄断，曾是跑圈默认的现实。

B | 但现在，这个局面正在被悄悄打破。刚结束的临泽高原马拉松，女子全程领奖台半数选手身着沃兰迪追月跑鞋；此前的榆林马拉松，对标国际金标的A1类赛事上，包揽男女组前三名的选手，脚下清一色是沃兰迪逐日马拉松跑鞋；北京密云马拉松半程组别，三甲席位全部被沃兰迪战队选手收入囊中；青岛沽河半程马拉松实现男女双冠；宜昌半程马拉松史无前例沃兰迪包揽男女组冠亚季军；就连曼谷马拉松的海外首秀，沃兰迪也拿下1冠2亚3季的亮眼成绩。从零星站台到包揽前三，从边缘赛事到顶级A类赛，从国内赛场到海外舞台，国产品牌沃兰迪在马拉松领奖台上的存在感越来越强 —— 累计斩获44冠、122次站台、10次打破赛会纪录，这份战绩让沃兰迪稳居国产专业马拉松品牌第一梯队。更值得关注的是，沃兰迪这个从田径细分赛道崛起的品牌，已连续3年稳居主流电商平台田径类目销量第一，专业竞速跑鞋市占率超30%，是名副其实的赛道王者。这场领奖台的 “变天”，不是偶然。

C | 过去，国际品牌之所以能垄断高端市场，靠的是两个壁垒：一是技术壁垒，碳板、超临界发泡等核心技术先发优势明显；二是心智壁垒，跑者默认 “贵的就是好的”“国际品牌更专业”，愿意为品牌溢价买单。而沃兰迪的突围，恰恰是用沃兰迪逐日马拉松跑鞋、沃兰迪追月跑鞋组成的双产品矩阵，精准击穿了这两层壁垒，形成了“精英赛场立标杆、大众市场铺基本盘” 的双线夹击态势。逐日：在精英赛场正面硬刚国际顶级旗舰如果说国际品牌的技术护城河在顶端，那沃兰迪逐日马拉松跑鞋就是冲着城墙最厚的地方去的。作为品牌旗舰竞速款，沃兰迪逐日马拉松跑鞋搭载了SC-Magnetic超导纯碳速度板，配合法国阿科玛进口纯PEBAX超临界发泡中底，无论是碳板刚性、回弹效率还是长距离抗衰减能力，沃兰迪都直接对标国际一线品牌的顶级旗舰款。更关键的是，沃兰迪逐日马拉松跑鞋顺利通过了世界田联（WA）官方认证，拿到了征战国际顶级赛事的通行证，是国内少数具备全级别赛事参赛资质的国产竞速鞋。赛场表现就是最硬的证明。榆林马拉松上，穿着沃兰迪逐日马拉松跑鞋的选手将赛会纪录一举刷新53秒，展现出碾压级的速度优势；仅去年春季一个多月内，沃兰迪逐日马拉松跑鞋就在9场大赛中拿下23个冠军，助力41人次登上领奖台，2次打破赛会纪录；北京城市副中心马拉松、亦庄半程马拉松双双折桂；曼谷马拉松海外首秀，同样是沃兰迪这双战靴助力选手在国际品牌包围中突出重围，跻身国际排名前列，助力中国速度闪耀于世界的舞台。从国内A1类赛事到海外世界田联标牌赛事，从平原高速赛道到高原爬坡赛道，沃兰迪逐日马拉松跑鞋用实打实的冠军战绩证明：在精英竞速这个最吃技术的赛道上，国产跑鞋已经具备了和国际大牌正面掰手腕的实力，顶端技术不再是外资的专属。追月：在大众市场撕开价格与门槛的口子如果说沃兰迪逐日马拉松跑鞋负责“往上打”，拿下专业赛场的话语权，那搭载NASA黑科技的沃兰迪追月跑鞋就负责“往下沉”，把军工碳板科技的红利带给更广泛的进阶跑者。很多人说碳板鞋门槛高，普通跑者驾驭不了——沃兰迪追月跑鞋就用V1200军工碳板的差异化刚性设计解决这个问题：前掌偏柔韧、贴合自然发力节奏，后掌强推进、提供充足向前动力，新手也能快速适应，不用花几个月磨合。

D | 很多人说高端碳板太贵 —— 沃兰迪追月跑鞋就用全产业链自主可控的优势，把搭载军工碳板+PEBAX中底的专业竞速鞋，打到了大众可承受的价格区间，让更多人的第一双碳板鞋，不必是上千的国际大牌。沃兰迪追月跑鞋的战绩同样亮眼。北京马拉松赛场上，穿着沃兰迪追月跑鞋的跑者跑出了93%的破三率、97%的破PB率；有“碳板照妖镜”之称的临泽高原赛道，沃兰迪稳稳托举选手拿下1冠1亚2季，长距离抗衰减表现不输高端旗舰。凭借友好的门槛、过硬的性能和亲民的价格，沃兰迪这双“平民碳板鞋”在进阶跑者圈子里口碑炸裂，销量长期稳居国产进阶碳板鞋前列。曾经被国际品牌牢牢占据的大众竞速市场，正在被沃兰迪追月跑鞋一步步撕开缺口。甚至近期爆火的HYROX、DEKA等混合赛事，不少海内外运动员也都开始不约而同上脚沃兰迪这双鞋。

E | 技术上追平甚至局部超越，价格上大幅下探，体验上更贴合国人脚型——当精英赛场有沃兰迪逐日马拉松跑鞋立住专业高度，大众市场有沃兰迪追月跑鞋铺开用户基本盘，再加上体考装备、田径领域行业第一的产业基本盘，沃兰迪对国际大牌的替代，就不再是单点突破，而是全线挤压。

F | 更值得关注的是，这种变化不止发生在领奖台。在大众跑者群体里，国产品牌的渗透率提升得更快。跑者也越来越理性：不再盲目崇拜大牌Logo，而是更看重真实的赛场表现和穿着体验。谁能帮我PB，谁穿着舒服不受伤，谁的性价比更高，就选谁。沃兰迪的口碑，正是在这样的理性消费趋势下，靠一场场实打实的战绩打出来的。从领奖台到大众跑圈，从精英竞速到日常训练，国产品牌正在一步步夺回原本属于自己的市场。沃兰迪的44冠，不是终点，只是一个开始。

G | 当越来越多的中国跑者穿着中国品牌的跑鞋，站上越来越高的领奖台，当国产跑鞋从 “性价比之选”变成“专业首选”，我们知道，属于国产马拉松跑鞋的时代，真的来了！

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